| Citrulline, a non-essential amino acid synthesized in the intestinal tract from Glutamine, converts to Arginine in a biochemical process involving Aspartic Acid and two necessary enzymes, Ornithine Transcarbamoylase and Argininosuccinate Synthetase. As a precursor to Arginine, It has a sparing effect on Arginine enabling an increase in Nitric Oxide production. Nitric Oxide (NO) is very important for endothelial support and cardiovascular health. Citrulline increases energy and stimulates the immune system, as well. Citrulline is also an essential component of the Urea Cycle, and functions along with Ornithine and Arginine to convert ammonia into Urea. High ammonia levels are extremely toxic and can cause liver damage and neurological impairment. Supplementation with Citrulline has been very beneficial in a genetic disorder called Ornithine Transcarbamoylase (OTC) Deficiency.
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