Red clover, a wild plant used as grazing food for cattle and other livestock, has also been used medicinally to treat a wide array of conditions. These have included cancer, mastitis (inflammation of the breast), joint disorders, jaundice, bronchitis, spasmodic coughing, asthma, and skin inflammations, such as psoriasis and eczema.

While not all studies are thoroughly convincing, several studies of a proprietary extract of red clover isoflavones suggest that it may significantly reduce hot flashes in menopausal women. Menopause increases a woman's risk for developing osteoporosis (significant bone loss). Some studies suggest that a proprietary extract of red clover isoflavones may slow bone loss and even boost bone mineral density in pre- and perimenopausal women.

Menopause increases a woman's risk for developing cardiovascular disease. Supplementation with red clover isoflavones has been associated with a sizeable increase in high-density lipoprotein (HDL) cholesterol, or "good" cholesterol in pre- and postmenopausal women, leading some researchers to believe that these isoflavones may help protect against cardiovascular disease. Other studies, however, have refuted this finding. Interestingly, one recent study found that menopausal women taking red clover supplements experienced a significant improvement in arterial compliance (a measure of the strength and resilience of the arterial walls). Arterial compliance diminishes during menopause and may increase a woman's risk for heart disease.